This paper addresses the problem of unknown input fractional-order functional state observer design for a class of fractional-order time-delay nonlinear systems. The nonlinearities consist of two parts where one part is assumed to satisfy both the one-sided Lipschitz condition and the quadratically inner-bounded condition and the other is not necessary to be Lipschitz and can be regarded as an unknown input, making the wider class of considered nonlinear systems. By taking the advantages of recent results on Caputo fractional derivative of a quadratic function, we derive new sufficient conditions with the form of linear matrix inequalities (LMIs) to guarantee the asymptotic stability of the systems. Four examples are also provided to show the effectiveness and applicability of the proposed method.