In ESL learning, successful English vocabulary learning is a vital part of acquiring English. However, the current teaching and learning English vocabulary in University of Information and Communication Technology gained little success due to the traditional face-to-face instruction model and some limitations related to large class size, time constraints, students’ demotivation and ability. In this experimental study, we presents meticulously the process to design the vocabulary lessons on Quizlet and vocabulary reading practices on Edmodo website, and then experiment these vocabulary learning activities on the experimental group. The result collected from pre-test and post-test reveals that there is a significant improvement in vocabulary knowledge in experimental group in comparison with the control one. This study is a useful source of reference for those keen on applying ICT for vocabulary teaching and learning in particular and in English education in general.