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Tên STUDY ON SYNTHESIS AND ANALYSIS OF DIASTEROISOMER OF β-LACTAM
Lĩnh vực Hóa - Công nghệ thực phẩm
Tác giả 1Phạm Thị Thắm, 3Nguyễn Tiến Dũng, 1Phạm Thế Chính, 2Ngô Thị Thuận, 1Nguyễn Văn Tuyến
Nhà xuất bản / Tạp chí Tạp chí Hóa học Năm 2013
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The β-lactamn are class of compound with interesting biological activities such as antibacterial, antifungal and cholesterol absorption inhibition. The β-lactams also serve as synthons  for many biologically important classes of organic compounds. This article describes the synthesis of β-lactam from kenten, bearing phenoxy-group and imines, bearing phenyl-group. By mean of this synthesis, the compounds of cis-β-lactam were obtained in a good yield. The structure of products were elucidated by  the NMR spectrocopy.These diastereoisomers of β-lactam were analyzed by HPLC method.  Result of analysis was high stereoscopic selectivity of 9a-d (de ~ 97%).

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