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Tên Study on diastereoselective synthesis of β-lactams
Lĩnh vực Hóa - Công nghệ thực phẩm
Tác giả Phạm Thị Thắm1, Phạm Thế Chính1, Đặng Thị Tuyết Anh1, Ngô Thị Thuận2, Nguyễn Văn Tuyến1
Nhà xuất bản / Tạp chí Tạp chí Hóa học Năm 2012
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The chemistry of β-lactam has taken an important place in organic synthesis due to their interesting biological activity. The direct routes to β-lactam via  the Staudinger kenten-imine cycloaddition reaction is interested, recently. Several article describes the synthesis of β-lactam from kenten, bearing phenoxy-group and imines, bearing phenyl-group by mean of Staudinger reaction is convenient method of the selective synthesis of  cis-β-lactam. In this article we report the synthesisof cis-β-lactam (9a-c) by mean Staudinger reaction in a good yield with high diastereoselectivity. The structure of products were elucidated by NMR spectrocopies

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